B cells drive responses of other immune cells, can be modified to prevent multiple sclerosis symptoms
Penn Medicine research finds that abnormally active B cell metabolism causes an inflammatory immune response in individuals with MS.
In the context of immunology, a prevailing view suggests that T cells are the primary drivers of immune response. However, new findings suggest another class of immune cells, B cells, can control responses of myeloid cells through the release of particular cytokines, which are small proteins that control the growth and activity of cells in the immune system.
In individuals with multiple sclerosis (MS), abnormally active respiration in B cells drives pro-inflammatory responses of myeloid cells and T cells, leading them to attack the protective sheath (myelin) that covers nerve fibers, and leading to nerve damage that causes symptoms of MS.
Now, recent research led by Amit Bar-Or of the Perelman School of Medicine shows how a new class of drugs known as Bruton’s tyrosine kinase (BTK) inhibitors corrects this abnormal activity in B cells. Published in Science Immunology, the study suggests these drugs could interrupt the dysregulated signaling pathways that lead to MS attacks, offering a potential new treatment avenue.
“Experts previously thought that T cells were the main orchestrators of responses by other immune cell types, and that MS was principally caused by overly activated T cells,” says Bar-Or, a professor of neurology and director of Penn’s Center for Neuroinflammation and Neurotherapeutics. “This research highlights that it is actually how multiple cell types interact that matters, and that B cells modulating myeloid cells play a much more active role in the immune system than we thought.”
In Senegal, the ambitious Dakar Greenbelt project seeks to create an extensive network of ecological infrastructure in and around the city to sustainably address environmental concerns and enhance urban life. With support from David Gouverneur and Ellen Neises, Ph.D. candidate Rob Levinthal in the Weitzman School of Design led two courses that included a field trip to Dakar, that culminated in students presenting their visions for parts of the Greenbelt.
From a desert to an oasis: Penn engages in ambitious greening effort in the Sahel
Students from the Weitzman School of Design journeyed to Senegal to help with a massive ecological and infrastructural greening effort as part of their coursework. The Dakar Greenbelt aims to combat desertification and promote sustainable urban growth.
As part of an undergraduate course, Penn faculty and students curated an Arthur Ross Gallery exhibition of works from the Neumann family’s extensive collection of modern and contemporary art.
The University’s nexus for technology transfer supports researchers in their innovative efforts, from CAR T to mRNA advancements that have dramatically reshaped the world.
