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SCALAR: A microchip designed to transform the production of mRNA therapeutics and vaccines
Silicon wafer with chips lightinhg in neon light.

Led by Michael Mitchell and David Issadore of the School of Engineering and Applied Science, a team of researchers has developed a platform that could rapidly accelerate the development of mRNA-based lipid nanoparticle vaccines and therapeutics at both the small and large scale, SCALAR.

(Image: iStock / Anatoly Morozov)

SCALAR: A microchip designed to transform the production of mRNA therapeutics and vaccines

Researchers have developed a platform that could rapidly accelerate the development of mRNA-based lipid nanoparticle vaccines and therapeutics at both the small and largescale, SCALAR.
Hard at work, crews make progress during summer construction
vagelos laboratory exterior

(On homepage): The Vagelos Laboratory for Energy Science and Technology, pictured in July 2023, features innovative sunshades designed to increase daylighting while blocking approximately 40% of light. A similar design of shades was recently used in London’s U.S. embassy building.

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Hard at work, crews make progress during summer construction

Ahead of the arrival of students, summer on campus bustles with construction teams advancing various building projects and maintenance work. Here, a look at what’s happening now.
Desmond Patton and the science of being human
Desmond Patton stands with arms crossed in front of a window, which mirrors his image

“Open-mindedness never stops, that growth in terms of becoming open never stops and cannot stop. That has become a critical value that I hold, that that this learning is never over,” Patton says.

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Desmond Patton and the science of being human

Penn Integrates Knowledge University professor Desmond Upton Patton discusses his research in social media and violence, finding an interdisciplinary career in social work, communication, data science, and psychiatry, and why his open-mindedness never stops.

Kristina García

‘In vivo’ RNA-based gene editing model for blood disorders developed
Microscopic rendering of mRNA gene editing.

Image: iStock/Ozgu Arslan

‘In vivo’ RNA-based gene editing model for blood disorders developed

Researchers from Penn Medicine and The Children’s Hospital of Philadelphia show that gene editing tools can be delivered via lipid nanoparticles, which would reduce cost and increase access to cutting-edge gene therapies.

Alex Gardner

Protein identified as a target for Alzheimer’s treatment
Microscopic rendering of tau proteins disintegrating microtubuli in a neuron axon.

Image: iStock/selvanegra

Protein identified as a target for Alzheimer’s treatment

New Penn Medicine research finds that a tau-regulating protein suppresses deterioration, and suggests replenishing the protein may improve cognitive and motor function.

Kelsey Geesler

Could psychedelics simultaneously treat chronic pain and depression?
Ahmad Hammo

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Could psychedelics simultaneously treat chronic pain and depression?

This summer, Ahmad Hammo, a rising third-year student in the School of Engineering and Applied Science, is conducting a pilot study to explore psilocybin’s potential as a therapy for chronic pain and the depression that often accompanies it. 

Liana F. Wait

Artificial intelligence is leveling up the fight against infectious diseases
Cesar de la Fuente at the BioPond in James Kaskey Memorial Park

César de la Fuente, presidential associate professor with appointments in the Perelman School of Medicine, School of Engineering and School of Arts & Sciences.

(Image: Eric Sucar)

Artificial intelligence is leveling up the fight against infectious diseases

In a new review, Presidential Assistant Professor Cesar de la Fuente and co-authors assess the progress, limitations, and promise of research in AI and infectious diseases.

Devorah Fischler