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Biology

A link between obesity and sleep loss may lie in studying worm metabolism
Microscopic image of C. elegans.

Caenorhabditis elegans (C. elegans), seen here under a microscope. (Image: University of Nevada, Reno)

A link between obesity and sleep loss may lie in studying worm metabolism

Penn researchers find microscopic worms offer a surprisingly good model for studying how metabolism regulates sleep in humans and other mammals.

Penn Medicine

Penn labs get creative to stay productive, connected
thomas mallouk lab with researcher

Penn labs get creative to stay productive, connected

In the face of a pandemic that has shuttered most physical laboratories across campus, researchers have shifted gears, maintaining work and social ties through grant- and manuscript-writing, virtual journal clubs, online coffee breaks, and more.

Michele W. Berger

A quick pivot turns an infectious disease class into timely education
David Roos taking a selfie while teaching a class online, with scientific materials on the screen behind him

David Roos shifted his infectious disease course online, as required when Penn’s campus closed. But he also adapted its content to tackle some of what is happening in the world around the novel coronavirus. (Image: Courtesy of David Roos)

A quick pivot turns an infectious disease class into timely education

Students in David Roos’ upper-level biology course had been studying pandemics. Now they get to learn in real time how public health scientists attempt to understand COVID-19.

Katherine Unger Baillie

A critical enzyme for sperm formation could be a target for treating male infertility
Side-by-side microscopic images of cell spindle during meiosis. Left image shows green with pink in the middle, right shows green with pink spots throughout.

The activity of the Skp1 protein is crucial for sperm formation, Penn Vet scientists found. In a dividing sperm precursor cell, chromosomes (in purple) normally align in the middle, as shown on the left. But in cells lacking Skp1, as shown on the right, chromosomes fail to align and are instead distributed chaotically around the cell. (Image: Courtesy of the Wang laboratory)

A critical enzyme for sperm formation could be a target for treating male infertility

The protein, SKP1, drives a key transition step in male meiosis, the type of cell division process that results in sperm, School of Veterinary Medicine researchers found.

Katherine Unger Baillie

Penn establishes center to accelerate coronavirus research
Two gloved hands hold a syringe and needle in a lab setting

Penn establishes center to accelerate coronavirus research

The Center for Research on Coronaviruses and Other Emerging Pathogens aims to advance research efforts and support development of new therapies and vaccines.

Penn Today Staff

The biology of coronaviruses: From the lab to the spotlight
Gloved hands hold a dropper over a tray of glass vials in a lab

The biology of coronaviruses: From the lab to the spotlight

The recent coronavirus outbreak, COVID-19, has been swift, but according to microbiology professor Susan Weiss, it didn’t come out of nowhere. Coronaviruses have been around for a long time, and new strains have transformed and may continue to emerge.

Penn Today Staff

Helpful interactions can keep societies stable
A heron stands in a swamp

Mutualistic interactions abound in nature, yet classical ecology models predicted they shouldn’t. With a new approach, biologists from Penn clarify what the old predictions missed. (Image: Erol Akçay)

Helpful interactions can keep societies stable

New work by Erol Akçay of the School of Arts and Sciences and Jimmy Qian, a recent alum, challenges 50-year-old predictions that mutualistic interactions make a community unstable.

Katherine Unger Baillie

A promising new strategy to help broken bones heal faster
X-ray of wrist with broken bone

In a mouse model of diabetes, a plant-grown compound helped bone fractures heal faster.

A promising new strategy to help broken bones heal faster

To improve how broken bones heal in people with diabetes, the School of Dental Medicine’s Henry Daniell, Sheri Yang, and colleagues are leading work to develop an affordable oral therapy—grown in plants.

Katherine Unger Baillie