News from

Research

Reset All Filters
1353 Results
Mitochondrial vulnerability and neurovasculature function connection impacts neuropsychiatric disease

Mitochondrial vulnerability and neurovasculature function connection impacts neuropsychiatric disease

In a new study led by Penn’s School of Veterinary Medicine and Children’s Hospital of Philadelphia, researchers have found that mitochondrial dysfunction in the blood-brain barrier may lead to neuropsychiatric disease in some patients with 22qDS. The researchers also demonstrate that a class of FDA-approved cholesterol drugs could potentially be repurposed to treat this dysfunction.

Centuries after discovery, red blood cells still hold surprises
Four microscopic views of red blood cells.

In these microscopic close-ups, samples of red blood cells aggregate from left to right, becoming more compact despite the absence of platelets, long thought essential to clotting.

(Image: Rustem Litvinov)

Centuries after discovery, red blood cells still hold surprises

In a new collaborative study, researchers at Penn turned to mechanical engineering to understand how blood clots can compact, even without platelets.

Ian Scheffler

2 min. read

Nudging populations toward better health
Kevin Volpp.

Kevin Volpp is the Mark V. Pauly President’s Distinguished Professor at the Perelman School of Medicine and Health Care Management at the Wharton School, and director at the Center for Health Incentives and Behavioral Economics.

(Image: Courtesy of the Wharton School)

Nudging populations toward better health

Kevin Volpp, Mark V. Pauly President’s Distinguished Professor at the Perelman School of Medicine and Health Care Management at the Wharton School, discusses how behavioral health interventions can improve public health outcomes.

From the Regulatory Review

2 min. read

International collaboration on nursing and midwifery in the Caribbean deemed a success, according to new study

International collaboration on nursing and midwifery in the Caribbean deemed a success, according to new study

A new publication the International Nursing Review highlights the success of an international partnership working to strengthen nursing and midwifery in the Caribbean, led by Penn Nursing’s Eileen T. Lake and Carmen Alvarez. The initiative supports the strategic goals of the Pan American Health Organization/World Health Organization for nursing and midwifery workforce development in the Caribbean region.

The poetry of ancient math
Medieval mathematical manuscript written in vernacular Malayalam script on palm-leaf

Medieval mathematical manuscript written in vernacular Malayalam script on palm-leaf at the Oriental Research Institute and Manuscripts Library, Thiruvananthapuram, India. Ph.D. student Priya Nambrath is using manuscripts like these to better understand “a deeply grounded and long-lasting mathematical tradition.”

(Image: Courtesy Priya Nambrath)

The poetry of ancient math

The methods and findings of pre-modern Indian mathematicians remain poorly understood. Priya Nambrath, a doctoral candidate in the School of Arts & Sciences’ Department of South Asia Studies, wants to change that.

From Omnia

2 min. read

Study finds American women may benefit from IUD only available in Europe and Canada

Study finds American women may benefit from IUD only available in Europe and Canada

New research led by researchers at Penn’s Perelman School of Medicine suggests the Food and Drug Administration should consider approving more and smaller IUDs. While the larger IUDs are 99% effective at preventing pregnancies over three years, the researchers have found the mini IUDs were still very effective (at 95%) for the same duration.

Stem cell discovery could be key to healing tough-to-fix fractures

Stem cell discovery could be key to healing tough-to-fix fractures

The ability of a stem cell originating in skeletal muscle to turn into bone could hold the key to bone healing after catastrophic fractures, according to research at Penn’s Perleman School of Medicine. The researchers find that Prg4+—a type of stem cell that originates in the muscles that support the skeleton—is crucial to bone repairs because the cells could actually transform from muscle cells to bone cells.

Investigating barriers to menopause care for Medicaid patients
Eri Maeda standing outdoors against a brick wall and smiling, facing forward.

Eri Maeda, a rising third-year in the College of Arts & Sciences, spent her summer in the Penn Undergraduate Research Mentoring Program (PURM) studying the impact of insurance status on menopause care access in the U.S. A neuroscience major pursuing a pre-medicine path, Maeda has gained new insights and research skills throughout her PURM experience.

nocred

Investigating barriers to menopause care for Medicaid patients

Rising third-year Eri Maeda dedicated her summer to a Penn Undergraduate Research Mentoring Program project exploring how insurance status may shape access to menopause care in the U.S.

4 min. read

Researchers advance mRNA delivery to the retina using stabilized lipid carriers

Researchers advance mRNA delivery to the retina using stabilized lipid carriers

The efficient delivery of synthetic mRNA to the retina has been a barrier to mRNA-based treatments for vision loss. A new study from Penn Vet has found that coating mRNA-lipid complexes (lipoplexes) with polyethylene glycol (PEG)-lipid derivatives can enhance their stability and penetration into retinal tissue.